A new article published in Pediatric Obesity discussed that reduction in the consumption of added sugars and sugar-sweetened beverages (SSBs) is a key focus of public health recommendations for a healthy diet among children. It was suggested that the use low-calorie sweeteners (LCSs) could be considered as a strategy for lowering added sugar intake. The authors reported that the consumption of LCSs is increasing worldwide with the most marked rise observed among children and adolescents. However, the extent to which LCS consumption is helpful or harmful for weight management remains controversial, particularly when LCS consumption begins in childhood. This article summarized the existing literature examining effects of pediatric LCS consumption on appetite, energy intake, and body weight. The findings showed that although positive associations between LCS consumption and weight gain are reported in observational analyses, the majority of intervention studies report benefits of LCSs for reducing excessive child weight gain. A number of potential mechanisms have been proposed to explain the effects of LCS on body weight, including LCS-induced promotion of appetite and energy intake. However, studies assessing effects of beverages with LCSs (LCSBs) compared to SSBs on child appetite report mixed findings. Some demonstrate that children completely compensate for the diluted energy content of LCSBs by eating more solid food calories at subsequent meals compared to children administered SSBs, while others report a reduction in total energy intake with LCSB ingestion. Therefore, future prospective studies are warranted to investigate the effects of LCS use during childhood.