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Incidence of pituitary autoantibodies in idiopathic diabetes insipidus |
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Incidence of pituitary autoantibodies in idiopathic diabetes insipidus
eMediNexus,  30 April 2019
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#Diabetes and Endocrinology

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A new article published in the Central European Journal of Immunology evaluated the occurrence of autoantibodies against the pituitary microsomal fraction. This study included 33 sera of diabetes insipidus patients and 10 control sera obtained from 10 healthy persons. In all patients the secretion of pituitary hormones and thyroid autoantibodies was assessed. Human pituitaries were obtained during autopsy and homogenized in 0.01 mol/l, pH 7.4 phosphate buffer. Autoantibody evaluation was conducted. The results showed the presence of autoantibodies against the pituitary in 23 out of 33 patients. Sera of 15 patients reacted to the pituitary microsomal fraction protein of 55 kDa while 10 sera reacted to the pituitary antigen of 67 kDa. Furthermore, 5 sera reacted to the 60 kDa antigen, 5 sera to 52 kDa protein, 3 sera to 105 kDa protein, 3 sera to the 97 kDa antigen and 2 sera to pituitary antigen of 92 kDa weight. Hence, the findings suggested that pituitary autoantibodies against 55, 60 and 67 kDa antigens occurred frequently.

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