Diffusion-weighted imaging and pathology of chronic kidney disease.


eMediNexus    13 November 2017

A new study published in Abdominal Radiology investigated the value of diffusion weighted imaging DWI for assessing histopathologic changes observed in chronic kidney disease CKD . In this study 52 patients with CKD were enrolled who underwent DWI before renal biopsy. In these patients the renal apparent diffusion coefficient ADC values and histopathologic changes were analyzed. The results revealed negative correlations between the right renal ADCs and scores of tubulointerstitial lesions the severity of tubular atrophy and the severity of interstitial fibrosis. Whereas there were no correlations between the ADCs and scores of glomeruli and peritubular vessel lesions. Moreover there were significant differences among groups based on pathology types. Furthermore there was no significant relationship between renal ADCs and the pathologic classification. From the findings it was inferred that DWI may be helpful to detect tubulointerstitial injury including tubular atrophy and interstitial fibrosis. It was speculated that DWI may be a potentially effective auxiliary method to help nephrologists in the evaluation of patients with CKD.

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