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Use of antidepressants that strongly inhibit serotonin is associated with a somewhat lower risk for ischemic stroke compared to agents that weakly inhibit the neurotransmitter, suggests a large, population-based study.
Investigators found a 12% reduced risk for ischemic stroke among study participants who were currently taking a stronger selective serotonin-reuptake inhibitor (SSRI) or third-generation antidepressant compared to those taking a weaker inhibitor of serotonin. The study was published online August 7 in Neurology.