Dynamics in prevalence of Down syndrome in children with congenital heart disease.


eMediNexus    17 November 2017

A new study published in the European Journal of Pediatrics assessed dynamics in the prevalence of children with congenital heart disease CHD and Down syndrome in Germany in relation with phenotype severity and gender. This study entailed data analysis of patients with CHD and Down syndrome born between 1980 and 2014 registered with the German National Register for Congenital Heart Defects. The findings showed that the prevalence of children born with both Down syndrome and CHD was constant between 2005 and 2009 however this rate increased from 2010 to 2014. In addition among CHD groups complex and simple lesions became more equal since 2005. The number of simple lesions with shunt exhibited a peak prevalence in the period of 2010 2014. While atrioventricular septal defect was the most common CHD phenotype temporal changes were found within the group of CHD phenotypes over the observation period. The findings of this study indicated a growing number of CHD and Down syndrome survivors. It was speculated that this may be the result of improved medical management and progress in educational social and financial support.

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