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Adding metformin to standard inhibitors of epidermal growth factor receptor (EGFR) and tyrosine kinase inhibitors (TKIs) significantly improved both progression-free and overall survival in advanced lung adenocarcinoma – with no significant increase in adverse events, a randomized phase II study found.
Investigators found a significantly longer median progression-free survival with EGFR-TKIs plus metformin: 13.1 months (95% CI 9.8-16.3) compared with 9.9 months (95% CI 7.5-12.2) for standard EGFR-TKIs (hazard ratio 0.60, 95% CI 0.40-0.94, P=0.03). The median overall survival was also significantly longer for patients receiving combination therapy: 31.7 months (95% CI 20.5-42.8) vs 17.5 months (95% CI 11.4-23.7, P=0.02). The findings are published in JAMA Oncology.