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A new article published in the British Journal of Hospital Medicine described systemic sclerosis as a complex autoimmune connective tissue disease which carries a significant burden of disease-related morbidity including potentially life-threatening complications. This article reported that systemic sclerosis can affect all the major organs and despite it being uncommon, the disease requires hospital-based specialists for patient care. Vascular disease or Raynauds phenomenon, is an almost universal symptom in patients with systemic sclerosis and is often the earliest manifestation. In addition, systemic sclerosis has a propensity to overlap with other rheumatological conditions like rheumatoid arthritis and myositis. The authors stated that in the past few decades, there have been major developments in the understanding of the pathogenesis of systemic sclerosis that have led to advances in treatment, such as those for the management of various organ-based complications. Furthermore, autologous haemopoietic stem cell transplantation is a potential emerging treatment in highly selected patients.