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Instead of using drugs to directly kill TB bacteria, researchers at the Indian Institute of Technology (IIT) Ropar have directly stimulated the immune system to kill the bacteria.
This was achieved by using small molecules (ligands) to stimulate two specific receptors (CLEC4E and TLR4) found on the surface of white blood cells (macrophages) to kill the bacteria. The two receptors are copiously expressed on the surface of the macrophages, and activating them helps regulate the cell function. Once activated, the ability of the macrophages to reduce the TB load and eliminate the bacteria gets enhanced through increased autophagy… (The Hindu, November 2, 2019)