If you have depression, a thorough physical exam and careful medical history should be evaluated to pinpoint a physical source of the problem for an appropriate treatment. In individuals with depression, do not only look for what’s going on in the mind and brain, but also check what’s going on in the body. Many medical problems are linked to mood disturbances.

Over 50% of heart attack survivors and those with cancer report feeling depressed. Depression is also linked to diabetes, Parkinson’s and other chronic conditions. Thyroid disorders also affect mood. Overactive thyroid can cause mania and underactive thyroid can cause depression. Other medical conditions associated with mood disorders include certain neurological conditions (multiple sclerosis, Parkinson’s disease, Alzheimer’s), other hormonal imbalances, and lack of vitamin B₁₂.

Depression can affect the course of a physical disease. Depression is linked with slower recovery from a heart attack and an increased risk for future heart trouble.