Mitochondria-Targeted Antioxidant Mito-Tempo Protects Against Aldosterone-Induced Renal Injury.


eMediNexus    04 December 2017

The goal of a new study published in Cell Physiology and Biochemistry was to determine whether a mitochondria-targeted antioxidant (Mito-Tempo) could prevent Aldo-induced kidney damage, in vivo. This experiment entailed treatment of C57BL/6J mice with Aldo and/or Mito-Tempo (or ethanol as a control) for 4 weeks. It was observed that when compared to control mice, Aldo-infused mice exhibited impaired renal function, increased mitochondrial reactive oxygen species (mtROS) production and mitochondrial dysfunction (MtD), Nlrp3 inflammasome activation and elevated endoplasmic reticulum stress (ERS). The results demonstrated that the administration of Mito-Tempo significantly improved renal function and MtD, and reduced Nlrp3 inflammasome activation and ERS, in vivo. Hence, it was concluded that mitochondria-targeted antioxidants may attenuate Aldo-infused renal injury by inhibiting MtD, the Nlrp3 inflammasome, and ERS in vivo. Thus, it was stated that targeting mtROS might be an effective strategy for preventing chronic kidney disease (CKD).

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