The objective of this study was to examine of skin microbial landscape and immune-endocrine parameters and the advanced treatment efficacy in patients with different clinical progression of psoriasis by narrowband UVB phototherapy.

89 patients with psoriasis comprising of 51 men and 38 women, aged 18-60 were examined. The comparison group comprised of 43 psoriasis patients that were comparable by age, sex and clinical progression with those from the main group comprised of 46 patients. Cytokine levels IL-4, IL-8, IL-10, along with TNFα, thyroglobulin (Tg) autoantibodies, thyroid peroxidase (TPO) and microbial flora of skin were assessed in psoriasis patients.

The study revelaed that conventional therapy does not had enough corrective impact on immune- endocrine disorders. The use of narrow-band light therapy has displayed that it has a focused corrective impact on cytokine production and on lesions of skin automicroflora in psoriasis patients. Narrow-band light therapy also had a modulating effect on the level of TPO and Tg autoantibodies.

The study concluded that using UVB (311 nm) therapy in psoriasis patients allows improved efficacy of treatment and can also limit clinical signs by achieving remission. A significant improvement in patients’ health was seen without any negative dynamic changes.

Source: Astsaturov HY, Syzon OO, Andrashko YV. Skin microbial landscape and immune-endocrine parameters in patients with psoriasis by using narrowband UVB phototherapy. Wiad Lek. 2020;73(1):7-11.