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Current smoking has been found to be associated with increased odds of a severe phenotype of Crohns disease after adjustment for the use of biologic therapy, suggest researchers.
A multivariate analysis revealed that the use of biologic therapy was tied to increased risk of severe disease phenotype, with an odds ratio of 2.137 (95% CI 1.471-3.106). However, after adjustment for biologic use, the risk for smokers for severe disease was nearly twofold higher (OR 1.930, 95% CI 1.112-3.350) compared to nonsmokers or former smokers, reported Neeraj Narula, MD, of the University of Ottawa, and colleagues. The findings were presented at the virtual Advances in Inflammatory Bowel Disease meeting… (Medpage Today)