Cough Update: Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy |
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Cough Update: Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy
eMediNexus,  14 January 2021
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Patients undergoing bronchoscopy can experience problems such as anxiety and cough, requiring various doses of sedatives and analgesics.

A study published in the Journal of Bronchology & Interventional Pulmonology investigated the effect of premedication with dextromethorphan on patients cough and anxiety, and the use of analgesics/sedatives during flexible bronchoscopy (FB).

In this randomized, double-blind, placebo-controlled, prospective study was performed to assess the effect of dextromethorphan premedication on patients who underwent diagnostic bronchoscopy. Seventy patients included in this study were randomly allocated into two groups – group A consisted of 35 patients who received dextromethorphan before FB; and group B consisted of 35 patients who received a placebo.

It was found that the group that was premedicated with dextromethorphan had lower complaint scores, significantly less coughing, significantly less stress assessed by the patient and the physician evaluation, shorter total procedure time and fewer midazolam requirements during FB.

In inference, it was stated that considering its safety profile, dextromethorphan premedication is an effective approach to facilitate the performance of FB for the physician and could improve patient comfort.

Source: Journal of Bronchology & Interventional Pulmonology. 2017 Oct;24(4):263-267. doi: 10.1097/LBR.0000000000000385.

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