HCM: Epidemiology, Genetics and Risk Stratification


Dr Ajay Bahl, Chandigarh    05 January 2018

  1. Mutations are most commonly found in genes encoding myosin heavy chain (MYH7) and myosin-binding protein C (MyBPC3).
  2. HCM is the commonest cause of sudden death in young individuals. Sudden death may be the first presentation of HCM.
  3. Screening of first-degree relatives of the patient should be advised.
  4. Family screening may be either clinical, ECG and echocardiography based or by genotyping in case a mutation is identified in the proband.
  5. Risk stratification for sudden death is important since patients at high risk of sudden death may be offered ICD implantation.

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