HF patients are at increased risk of CV and respiratory related hospitalizations compared with the general public. Vaccination coverage in HF patients is poor and requires sensitization regarding vaccination efficacy and safety. The evidence to date suggests that vaccination represents a low-cost intervention that may be able to prevent the significant morbidity, mortality and system-wide costs associated with HF. HF patients should receive routine adult immunization to decrease the incidence of vaccine-preventable disease. India needs to immediately address the challenge of adult immunization. In absence of specific vaccination guidelines or schedule for people with cardiac disorders, adult vaccination must become part of routine immunization because these vaccines can save millions of lives in India alone especially in chronic risk diseases including HF.