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Complement in Hemolytic Uremic Syndrome

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Dr Aditi Sinha, New Delhi    11 January 2018

Alternative complement cascade dysregulation is proposed to work in patients of HUS. Other complement pathways implicated in HUS are factor H, factor I, membrane cofactor protein and thrombomodulin (Kavanagh D et al. Ped Nephrol. 2010;25(12):2431-42). The complement blockade is considered to be ideal, but is usually not feasible. PEX and immunosuppression are satisfactory in the management of anti-FH HUS (European Guidelines 2009). Long-term monitoring for relapses is recommended; allograft recurrence may occur.

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