A new article published in Frontiers in Medicine discussed that owing to the complex nature of chronic kidney disease (CKD), its associated comorbidities, frequent association with psychosocial distress, and very significant symptom burden, subjective patient experience could better inform the understanding of its true impact on patients quality of life. It was stated that patient-reported outcome measures are important tools in rendering patient-centered care and to attain patient engagement during the complex management process of CKD. Further, routine collection and use of patient-reported outcomes (PROs) in clinical practice may improve quality of care and outcomes, and may provide useful data to understand the disease from both individual and population perspectives. It was also acknowledged that health-related quality of life, apart from being an important outcome itself, is associated with clinical outcomes such as health care use and mortality. In summary, this review describes various PROs and implications of their use in the context of CKD.