Treatment of Acne Scare with Epidermal Growth Factor Combined with Fractional Carbon Dioxide Laser


eMediNexus    16 December 2022

Epidermal growth factor (EGF) boosts collagen production and sustains wound healing. However, there need to be more studies on fractional carbon dioxide (CO2) laser combined with EGF for treating acne scar.


The present study evaluated the efficacy and safety of fractional CO2 laser combined with topical EGF vs. fractional CO2 laser monotherapy for treating acne scars.


The study enrolled 23 patients with atrophic acne scars and subjected them to 3 monthly sessions of randomized split-face application of fractional CO2 laser along with topical EGF or placebo twice a day for 7 days after each laser session. It evaluated scar improvement at 1 month and 3 months post-treatment, along with wound healing response and adverse events.


The study observed:


  • Trial completion by 21 patients.
  • Significant superiority of EGF at 3 months post-treatment compared to placebo, using dermatologist grading and skin analysis system.
  • Similar wound healing responses between the groups.
  • Compared to the placebo, a significant decrease in the melanin index on the EGF side at 3 months post-treatment.
  • No allergic reaction to the topical EGF.


This study shows that treatment with topical EGF after ablative fractional CO2 laser improves the clinical appearance of atrophic acne scars, and it also decreases skin pigmentation after laser treatment. Using topical EGF with post-laser ablation is safe.


Source: Ratanapokasatit Y, Sirithanabadeekul P. The efficacy and safety of epidermal growth factor combined with fractional carbon dioxide laser for acne scar treatment: a split-face trial. J Clin Aesthet Dermatol. 2022;15(7):44-8.

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