1-Deoxysphingosine Might be a Novel Biomarker of Skin Barrier Dysfunction and Treatment


eMediNexus Editorial    20 January 2023

Skin diseases featuring epithelial barrier dysfunction show altered sphingolipid metabolism, which causes alterations in the stratum corneum intercellular lipid components and structure. Under pathological conditions, 1-deoxysphingolipids form atypical sphingolipids from de novo sphingolipid biosynthesis.


A study by Chung et al assessed the potential role of 1-deoxysphingolipids in skin barrier dysfunction secondary to X-ray and ultraviolet B (UVB) irradiation, both in vitro and in vivo. They also assessed alterations in the expression of 1-deoxysphingolipids in lesional human skin of atopic dermatitis.


They found increased 1-deoxysphingolipids in cultured normal human epidermal keratinocytes after X-ray irradiation. X-ray or UVB irradiation boosted 1-deoxysphingosine production in a reconstituted 3-dimensional (3D) skin model. To their excitement, treating with a physiological lipid mixture (multi-lamellar emulsion contained pseudoceramide), which can amplify the epidermal permeability barrier function, caused decreased 1-deoxysphingosine formation in a reconstituted 3D skin model. 


They investigated further using a hairless mouse model and found resembling preventive effects of physiological lipid mixture against 1-deoxysphingosine formation after X-ray irradiation. They also observed an increase in the level of 1-dexoysphingosine in the stratum corneum in lesional skin of atopic dermatitis.


Through their study, the investigators showed that 1-deoxysphingosine might be a novel biomarker of skin barrier dysfunction, and treatment with a physiological lipid mixture could prevent 1-deoxysphingosine production and consequent skin barrier dysfunction.


Source: Chung BY, Kim HO, Kang SY, et al. Increased 1-Deoxysphingolipids and skin barrier dysfunction in the skin of X-ray or ultraviolet B irradiation and atopic dermatitis lesion could be prevented by moisturizer with physiological lipid mixture. Ann Dermatol. 2020;32(4):306-18.

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