CNS Update: Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib


eMediNexus    25 February 2023

The present study evaluated the preemptive analgesic effect of a combination of pregabalin with celecoxib for lumbar spine surgery.


The study divided 60 lumbar spine surgery patients into two groups. It achieved Postoperative pain relief with intravenous patient-controlled analgesia with morphine. 


The study administered oral pregabalin (150 mg) and celecoxib (200 mg) 2 hrs before surgery in the preemptive analgesia group and placebo in the control group. It assessed Pain by visual analogue scale (VAS); and monitored side effects and morphine consumption until 48 hrs after surgery.

The study found-

  • Significantly lower VAS scores at rest and during movement in the preemptive analgesia group at most time points.
  •  Significantly lower morphine consumption in the preemptive analgesia group compared with the control group in the 24 first hours and 48 hrs. 
  • Similar H=hemodynamics, respiratory rate, and SpO2 in both groups. 
  • Significant sedation score at only the H8 time point. 
  • Similar incidence of nausea/vomiting in the preemptive group and the control group.


This study shows that Preoperative administration of pregabalin combined with celecoxib renders a good preemptive analgesia effect and reduces intravenous morphine consumption after lumbar spine surgery, with mild and transient side effects.


Drug Des Devel Ther. 2019 Jul 3;13:2145-2152. doi: 10.2147/DDDT.S202410. PMID: 31308627; PMCID: PMC6613459.

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