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Pediatric acute kidney injury and the subsequent risk for chronic kidney disease.

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eMediNexus    26 February 2018

A new article published in Pediatric Nephrology reported on the recent standardized AKI definition that has transformed the knowledge of AKI epidemiology and outcomes. It has been disclosed that in the short term, children with AKI experience greater morbidity and mortality. Meanwhile, observational studies have established that chronic renal sequelae are far more common after AKI events than previously known. Several studies have suggested that patients who develop AKI are at greater risk for subsequent development of chronic kidney disease (CKD). Here, the authors elaborated on a review which critically evaluated data regarding the association between AKI and CKD in children. Best practice approaches for future studies were described, including the use of consensus AKI criteria, the application of rigorous definitions for CKD and renal sequelae, and the inclusion of non-AKI comparator groups. In conclusion, an archetypal approach was recommended to follow-up care for the AKI survivors who may be at greater CKD risk, including children with more severe AKI, those with recurrent AKI episodes, patients who fail to achieve full recovery, and those with pre-existing CKD.

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