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Integrated strategy of differentially expressed genes associated with ulcerative colitis.

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eMediNexus    14 October 2017

A new study published in Molecular Medicine Reports aimed to further explore 12 microarray datasets from patients with ulcerative colitis (UC), for potential genetic pathogenesis of UC through a global bioinformatics view; which included identification of differentially expressed genes (DEGs), functional enrichments, protein protein interactions, transcriptional and post transcriptional regulation and drug gene associations. This integrated analysis screened 233 DEGs that were compared between UC and normal control tissue samples. The findings showed that transcription factors, such as TATA binding protein-1, nuclear factor-κB, and microRNAs were associated with 233 DEGs. Further analysis suggested that these DEGs were enriched in certain diseases, including inflammation, fibrosis, and immune system diseases, and were also associated with some drugs, including prednisone, collagenase and mycophenolate mofetil, which may provide choice for treatment of UC. Hence, it was stated that this study may provide novel insights into discovering potential molecular targets involved in the pathogenesis and treatment of UC.Reference1. Feng J, Gao Q, Liu Q et al. Integrated strategy of differentially expressed genes associated with ulcerative colitis. Molecular Medicine Reports. 2017. doi:10.3892/mmr.2017.7509.

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