The goal of a study published in The American Journal of Surgical Pathology was to examine the frequency and clinical correlates of rectal Paneth cells in pediatric patients. In this trial, 245 biopsies were obtained from patients of 2 weeks to 20 years old, in a pediatric tertiary care facility, between 2010 and 2011. The specimens were 193 endoscopic pinch biopsies and 52 rectal suction biopsies. It was observed that all 245 cases were endoscopically and histologically unremarkable with no prominence of eosinophils, no altered mucosal architecture, and no inflammation. While Paneth cells were present in 17.1% of the cases, and were found to be higher than in previous reports. On the other hand, only 1 out of 42 patients with rectal Paneth cells was subsequently diagnosed with Crohn’s disease. Moreover in this study, the incidence of Paneth cell cases was more predominant in the younger age-groups, and decreased with an increase in age. Additionally, constipation was the most common presenting symptom in patients with rectal Paneth cells and correlated to the presence of Paneth cells. From the findings, it was inferred that Paneth cells in otherwise unremarkable pediatric rectal biopsies are not rare and is a frequent occurrence in common conditions such as idiopathic constipation.