The purpose of a study published in the Journal of Pediatric Gastroenterology and Nutrition was to evaluate the tolerability, safety, and efficacy of polyethylene glycol (PEG) 3350 as a 1-day bowel preparation for colonoscopy in children. This was a prospective study of 45 children undergoing colonoscopy prescribed PEG 3350 without electrolytes mixed with a commercial electrolyte beverage. A basic metabolic panel was performed at the time of the clinic visit and just before colonoscopy. The trial included 44 patients (14 ± 3 years), of which one was excluded. All the remaining patients reported the preparation was easy to use or tolerable. Significant changes in sodium, potassium chloride, blood urea nitrogen, or creatinine did not occur. Furthermore, colonic preparation was rated as excellent in 23%, good in 52%, fair in 23%, and poor in 2% of patients. While, intubation of the ileum was successful in 100%. Therefore, it was concluded that one-day bowel preparation with high dose PEG 3350 mixed with electrolytes is tolerable, safe, and effective in children before colonoscopy.