Nontraditional hyperglycemia biomarkers by chronic kidney disease status in older adults with diabetes.


eMediNexus    24 October 2017

A new study published in the Journal of Diabetes investigated associations of hemoglobin A1c HbA1c glycated albumin and fructosamine with fasting glucose by chronic kidney disease CKD categories. In this cross sectional analysis 1 665 Atherosclerosis Risk in Communities Study participants with diagnosed diabetes and aged 65 years or more were recruited. The findings revealed that correlations of HbA1c glycated albumin and fructosamine with fasting glucose were lowest in individuals with severe CKD and very severe CKD. On the other hand associations of glycated albumin and fructosamine with HbA1c were equivalent across CKD categories. Hence it was inferred that in older adults with severe or very severe CKD HbA1c glycated albumin and fructosamine were not highly correlated with fasting glucose. The results indicated that there may be no particular advantage of glycated albumin or fructosamine over HbA1c for monitoring glycemic control in CKD.

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