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Behavior-based weight loss interventions with or without weight loss medications were associated with more weight loss and a lower risk of developing diabetes than control conditions. Weight loss medications, but not behavior-based interventions, were associated with higher rates of harms. These conclusions from a systematic review of evidence for the USPSTF on the benefits and harms of behavioral and pharmacotherapy weight loss and weight loss maintenance interventions in adults were published online September 18, 2018 in JAMA.