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Long noncoding RNA HOTTIP promotes endothelial cell proliferation and migration.

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eMediNexus    01 November 2017

A new study published in the Journal of Cellular Biochemistry demonstrated that long noncoding RNA lncRNA HOXA transcript at the distal tip HOTTIP expression level was higher in coronary artery disease CAD tissues than in normal arterial tissues. It was reported that the expression level of HOTTIP was upregulated in the proliferating endothelial cells induced by tumor necrosis factor TNF 945 or platelet derived growth factor PDGF BB. It was stated that ectopic expression of HOTTIP promoted endothelial cell proliferation and also increased the expression of proliferating makers cyclin D1 and proliferating cell nuclear antigen PCNA . Moreover elevated expression of HOTTIP promoted endothelial cell migration whereas downregulation expression of HOTTIP suppressed endothelial cell proliferation and migration. In addition this study determined that overexpression of HOTTIP induced 946 catenin expression and enhanced the downstream protein c Myc expression in the endothelial cell. Ectopic expression of HOTTIP increased endothelial cell proliferation and migration through the activation of Wnt 946 catenin pathway. From the findings it was speculated that HOTTIP might manipulate the endothelial cell proliferation and migration via activation of the Wnt 946 catenin pathway.

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