• In serial lesions, the FFR of individual lesions should not be used. Measure the pressure gradients across lesions during pull back with hyperemia to decide, which lesion is to be stented.
• In LM with LAD disease to decide which lesion is significant, place the pressure wire distal to LAD lesion; achieve adenosine hyperemia and record FFR:

        o  FFR >0.80: Both lesions insignificant, no stenting

        o  ≤0.80 and ≤0.60: Treat LAD and repeat FFR to assess LM stenosis

        o  ≤0.80 and >0.60: Place pressure wire in LCx to assess LM FFR

        o  FFR apparent: >0.80 - Stent LAD lesion; ≤0.80 - Consider treating both LM and LAD lesions.