• Separation of other forms of young-onset diabetes from inherited forms should be primarily sought.
• Delineating a Pedigree chart with an insight into other syndromes pattern of inheritance (autosomal dominant, autosomal recessive and mitochondrial) is critical.
• C-peptide measurements are cost-effective and critical in placing the origin of the disorder.
• Imaging of the abdomen to look for pancreatic pathology, other abdominal disorders and DXA scan to assess body composition are useful, depending on the disorder.
• Next-generation sequencing (NGS) technology is critical in identifying genetic disorders in a cost-effective and rapid manner.
• Interpreting NGS reports requires a thorough background of previous mutations. Testing and replication of results from family members with matching phenotypes are critical for novel variants.

It is important to distinguish other forms of young-onset diabetes from inherited forms. NGS technology is the key to identify genetic disorders rapidly.