• Peroxisome proliferator-activated receptor (PPAR) agonists work as integrators of inflammatory and metabolic signaling networks; work as lipid sensors; repress pro-inflammatory gene expression; fine-tune post-translational modifications and exert antiatherogenic effects.
• Potential of PPAR agonists is well-established in therapeutic areas related to lipid and glucose metabolism and inflammation such as type 2 diabetes mellitus, obesity, dyslipidemia and NAFLD and/or NASH.
• PPAR-g ligand may prevent loss of b-cell mass.
• PPAR-g activation reduces insulin resistance, preserves pancreatic b-cell function, improves cardiovascular risk profile.

PPAR agonists play significant roles in several diseases including primary biliary cholangitis, gout, non-small cell lung cancer, neurological diseases and ulcerative colitis.