Hospital. A system of integrated devices to substitute endocrine pancreas by: Sensing blood glucose level; determining the amount of insulin; delivering the appropriate amount. Glucose monitoring: Various types of sensors - noninvasive, minimally invasive, invasive: Algorithm to link blood glucose levels with insulin delivery: to develop thinking like pancreas; Automatic insulin delivery system: CSII (continuous subcutaneous insulin infusion) or CIPII (continuous intraperitoneal insulin infusion). Artificial pancreas (AP) development is ongoing: Major issues are due to unphysiological route for insulin infusion and need of glucagon; insulin only AP will be more practical but to manage physiology, algorithms from technology may provide alternative; CGMS technology improvement will be must to achieve this goal.