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Use of Fibrates in Metabolic Syndrome and Diabetes: Practical Tips

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Prof. Sudarshan Ramachandran, UK    26 November 2018

  1. The evidence for fibrates mainly exists in patients with elevated triglycerides and low HDL-C levels.
  2. Mechanisms leading to change in TGs and HDL-C levels may be different.
  3. Fibrates can lead to reversible hypercreatininemia and this phenomenon is especially important in type 2 diabetes.
  4. Improvements in liver function tests may be evident following fibrate therapy, perhaps with improvement in NAFLD. It is important to monitor for the rare paradoxical HDL-C reduction.

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