There are reports showing that appetite, control of body weight and energy compensation are influenced by the macronutrient composition of meals (amount of fat, carbohydrate and protein). Thus, manipulating the macronutrients helps in maintaining body weight. Reducing glycemic load is advisable to facilitate weight loss. As such, minor changes in caloric intake are unlikely to have a long-term impact. There is potential to develop a diet based on the nature of food items, rather than calorie content that will help to maintain a lower weight. Protein-based diet, compared to calorie restriction, is better in maintaining weight loss. Rather than concentrating specifically on the properties of individual foods, it should be remembered that it is the habitual pattern of eating that predisposes to obesity. Encourage the consumption of diets that are less likely to be associated with the gaining or regaining of weight. This will; however, involve considerations other than simply reducing calorie intake. Manipulating macronutrients for weight reduction would be important along with calorie reduction. Any diet which is sustainable for a longer time with good compliance should be advised.