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Treatment of HCV: Cirrhosis and DAA Failures

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Dr Paul J Thuluvath, Baltimore    06 December 2018

Treatment-emergent RASs, especially NS5A resistant RASs, are common, and have an impact on SVR when 2-drug DAA regimen with or without ribavirin is used:

  • NS3 RASs progressively disappear and are replaced by wild-type virus
  • NS5A RASs may persist for years
  • Testing for RASs is perhaps beneficial if 2-drug regimen with or without ribavirin is used.

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