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Probiotics and the Gut- Kidney Axis

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Dr R Vanholder, Belgium    28 December 2018

  • CKD is a devastating disease.
  • Role of the intestine in CKD morbidity: Loss of intestinal integrity, pro-inflammatory effect and generation of uremic toxins.
  • CKD disturbs the integrity of the intestinal epithelium.
  • The gut plays a pathophysiologic role by inducing inflammation and generating uremic toxins.
  • Probiotics may alter this chain of events by: An anti-inflammatory effect, reducing uremic toxins and preserving kidney function.
  • Probiotics attenuate hyperuricemia. They refrain the progression of CKD.
  • Evidence on the impact of probiotics could be strengthened.
  • As a preventive or therapeutic option for CKD, probiotics are of special interest, because of their low cost and safety.

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