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Why Psoriasis Vulgaris Recur After External Application of Glucocorticoids?

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Dr Jie Zheng, China    22 January 2019

  • Psoriasis is an immune-mediated chronic inflammatory skin disease, recurrence is its specific characteristic.
  • The reason or disease relapse after treatment is poorly understood.
  • T cells play a key role in the relapse of psoriasis with WT and Tcrd-/- mice or patients.
  • It was found that after glucocorticoid treatment, skin chemokines were significantly decreased at psoriasis skin, and dermal T transfer to peripheral blood in human or lymph node in mice.
  • After psoriasis relapse the chemokines and skin dermal T were increased at psoriasis skin again.
  • In Ccr6-/- or inhibit T-cell egress from lymph node with fingolimod, psoriasis relapse was relief.
  • These observations support the idea that chemokines and dermal γδ T cells are the key components in the pathogenesis of psoriasis relapse.
  • Anti-CCR6 treatment may be useful to keep long-term remission of psoriasis.

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