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High doses of vitamin B supplementation may put women at risk for fracture, suggests a new study published in JAMA Network Open.
In an analysis of more than 75,000 postmenopausal women, higher total intakes of vitamin B6 and vitamin B12 were both associated with a higher relative risk of hip fracture, reported Haakon E. Meyer, MD, PhD, of the University of Oslo in Norway, and colleagues. The relative risk was still significantly elevated when intake of the vitamins was isolated to supplements only, i.e., not including diet. It was noted that postmenopausal women who reported high intakes of both vitamins - 35 mg/d of B6 and 20 μg/d of B12 - had the highest associated risk for hip fracture compared with women who averaged the lowest intake - <2 mg/d of B6 and <10 μg/d of B12.