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Prepregnancy body mass index (BMI) may be a more significant risk factor for adverse maternal-fetal outcomes than weight gain during pregnancy, suggested a meta-analysis published online in JAMA.
"Results from this study suggest that maternal prepregnancy BMI was more strongly associated with adverse maternal and infant outcomes than gestational weight gain. Therefore, prepregnancy BMI may be an important focus for preconception counselling," state Ellis Voerman, from the Erasmus Medical Center, Rotterdam, the Netherlands, and colleagues with the LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group.
Voerman and colleagues conducted a meta-analysis of 25 cohort studies conducted in Europe and North America and pooled individual patient data from 196,670 women with singleton live births from 1989 to 2015. Adverse outcomes increased with increasing prepregnancy BMI, noted in 34.7% of underweight women, 34.1% of normal-weight women, 42.0% of women with overweight, and 50.2%, 56.8%, and 61.1% of women with obesity grades 1, 2, and 3, respectively.