The purpose of a new study published in Maternal & Child Nutrition was to provide evidence on effectiveness of various interventions on exclusive breastfeeding until six months in most low and middle income counties (LMICs) compared to standard care. This study selected experimental and observational studies with concurrent comparator promoting exclusive breastfeeding (EBF), conducted in LMICs with high country rates of breastfeeding initiation, through a systematic review and from PUBMED, Cochrane and CABI databases. Overall, 67 studies with 79 comparisons from 30 LMICs were identified. The findings revealed that at six months, intervention group infants were more likely to be exclusively breastfed than controls. Larger effects were obtained from interventions delivered by a combination of professional and lay persons in interventions spanning antenatal and postnatal periods, and when intensity was between four to eight contacts or sessions. Moreover, nearly every intervention conducted in LMICs increased exclusive breastfeeding rates. Hence, it was inferred that the choice of intervention should be driven by feasibility of delivery in the local context to reduce infant mortality.