A new study published in Frontiers in Microbiology aimed to investigate whether Chlamydia trachomatis physically interacts with Candida albicans. This experiment entailed the incubation of chlamydial elementary bodies (EB) in medium, alone or with C. albicans yeast or hyphal forms, for 1 hour. Subsequently, samples were formaldehyde-fixed and processed for immunofluorescence assays using anti-chlamydial MOMP or anti- chlamydial LPS antibodies. Replicate samples were replenished with culture medium and incubated at 35°C for 0-120 hours prior to fixation for immunofluorescence analysis or collection for EB infectivity assays. The results showed that both, C. trachomatis serovar E and C. muridarum EB bound to C. albicans yeast and hyphal forms. This interaction was not blocked by pre-incubation of EB with the Candida cell wall components, mannan or β-glucans, suggesting that EB interacted with a Candida cell wall protein or other structure. Additionally, bound EB remained attached to C. albicans for a minimum of 5 days. Infectivity assays demonstrated that EB bound to C. albicans are infectious, immediately following binding. But, once bound to C. albicans, EB infectivity decreased at a faster rate than EB in medium alone. Moreover, at 6 hours post binding, 40% of EB incubated in medium alone, remained infectious compared to only 16% of EB bound to C. albicans. Similarly, pre-incubation of EB with laminarin – a soluble preparation of β-glucan, alone or in combination with other fungal cell wall components, significantly decreased chlamydial infectivity in HeLa cells. From the findings, it was inferred that interactions between EB and C. albicans inhibit chlamydial infectivity, possibly by physically blocking EB interactions with host cell receptors.