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A study of two cross-sectional cohorts of 296 clinically normal adults published online Feb. 4, 2019 in JAMA Neurology has possibly shed some light on why more women than men develop Alzheimer’s disease. It was found that women with higher amyloid burden showed greater entorhinal cortical tau signal compared with men with higher amyloid burden. Sex differences did not exist in amyloid load or apolipoprotein E ε4 frequency.