A new study published in Post Reproductive Health evaluated the effectiveness of phytoestrogens on vaginal health and dyspareunia in peri- and post-menopausal women. This overview entailed searches from MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials databases from inception until August 2017 and included two systematic reviews and 11 RCTs. The findings revealed that isoflavones increased the maturation value and attenuated vaginal atrophy in post-menopausal women; topical isoflavones had beneficial effects on the vaginal atrophy. Similar efficacies were recorded for Pueraria mirifica and conjugated estrogen cream, on dryness, soreness, and irritation, as well as discharge and dyspareunia. Yet, conjugated estrogen cream was more effective compared to Pueraria mirifica, with respect to the maturation index improvement. On the other hand, comparison of fennel 5% vaginal cream with placebo gel showed significant differences in superficial cells, parabasal cells, and intermediate cells, but no difference was found between oral fennel and placebo in terms of superficial, parabasal, and intermediate cells nor the Maturation value. Meanwhile, the administration of 80 mg red clover oil had a significant effect on superficial, intermediate, and parabasal and vaginal dryness compared to placebo. Flaxseed had a trivial effect on the maturation value and genistein had a more prominent effect on the genital score. The severity of dyspareunia decreased by 27%. From the results, it was inferred that phytoestrogens have various effects based on administration route and type on the vaginal atrophy.