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Clinicopathological characteristics of patients with mucinous adenocarcinoma of the uterine cervix.

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eMediNexus    16 March 2019

The purpose of a new study published in the Journal of Gynecology Obstetrics and Human Reproduction was to describe the characteristics of a group of patients with mucinous adenocarcinoma of the uterine cervix. This retrospective descriptive study recruited women diagnosed with mucinous adenocarcinoma of the uterine cervix, from 1 January 2005 to 31 May 2016, in three hospitals in Lyon, France. The patients mean age was 42 years and 18 patients were premenopausal. All the cases of cervical adenocarcinoma were reanalyzed by an expert in gynecological pathology to retain the mucinous subtypes as defined in the 2014 WHO classification. Their clinical and pathological characteristics were analyzed. The results showed that among the 82 cases of cervical adenocarcinoma, 21 (26%) were diagnosed as mucinous. Ten were gastric type, of which four were in the extremely well differentiated form of minimal deviation adenocarcinomas, six were intestinal type, two were signet-ring cell type, and three were not otherwise specified. The characteristic symptom was metrorrhagia in eight cases (38%) and mucinous vaginal discharge in four (19%). Meanwhile, 15 (72%) of the cervical smear were abnormal. In addition, five (31%) of the 16 patients with gastric or intestinal type adenocarcinoma had a specific radiological presentation – multiple cysts of the uterine isthmus visible on ultrasound and with T2 hyper-intensity on MRI. From the findings, it was stated that mucinous adenocarcinoma is a rare form of cervical cancer that can be confused with other pathological types. It can be detected using cervical smears and should be suspected in cases of mucinous discharge and characteristic MRI features.

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