A new study published in BMJ Open investigated whether the decision on receiving neuraxial labor analgesia is associated with breastfeeding initiation success (BIS)—defined as exclusive breastfeeding until discharge associated with postnatal weight loss <7% at 60 hours from birth. This was a single-center community-based cohort study conducted in an Italian baby-friendly hospital, between 1 July 2011 and 22 September 2015. The study included women vaginally delivering singleton cephalic newborns and willing to breastfeed. Overall, 775 out of the 3628 women enrolled received neuraxial analgesia. The findings revealed that compared to women who tried to cope with labor pain, those who decided a priori to receive neuraxial analgesia had less BIS. Multivariable analyses with antelabor-only confounders confirmed both associations. Women who requested analgesia as a last resort had less BIS than did those successfully coping with labor pain in the bivariable analyses. Whereas, multivariable analyses with either antelabor-only or peripartum confounders did not confirm these associations. From the results, it was inferred that when compared to trying to cope with labor pain, a priori choice of neuraxial analgesia is negatively associated with BIS. On the contrary, when compared to having successfully coped with pain, requesting neuraxial analgesia as a last resort is not negatively associated with BIS.