A new study published in Epidemiology and Infection investigated associations between antibiotic therapies with recurrent urinary tract infections (UTIs). This retrospective study analyzed electronic medical records of 6,651 adolescent women diagnosed with a UTI at a US university student health center, between 2006 and 2014. Women were followed for 6 months for an incidence of recurrent infection. Associations in women who experienced UTI recurrence within 2 weeks were also considered for potential infection relapse. Overall, 1,051 instances of infection recurrence were recorded among the 6,620 patients indicating a prevalence of 16%. The findings suggested that Asian women were statistically more likely to experience infection recurrence whereas African-American were less likely. No significant associations were identified between antibiotic administered at the initial infection and the risk of infection recurrence. On the other hand, treatment with trimethoprim-sulphamethoxazole was significantly associated with increased odds of infection relapse. Thus, the results indicated that treatment with trimethoprim-sulphamethoxazole may lead to an increased risk of UTI relapse in adolescent females.