Specifically, Ragulator-interacting protein C17orf59 which limits mTORC1 activity, was upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, indicating contribution to Treg induction.">

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.

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eMediNexus    22 September 2017

It is known that obesity and type-2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3+ regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. A new article published in Cell Metabolism aimed to establish how T cells interlink environmental influences with adipocyte function. The article reported that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction, in vitro and in vivo. It was stated that CD4+ T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Foxp3+ regulatory T cell (Treg) induction. Specifically, Ragulator-interacting protein C17orf59 which limits mTORC1 activity, was upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, indicating contribution to Treg induction. By loss- and gain-of-function studies including Treg depletion and transfers in vivo, a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3+ Treg induction and adipose tissue function could be demonstrated. The findings of this study proposed a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.

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