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Investigation of the effects of various antibiotics against Klebsiella pneumoniae biofilms.

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eMediNexus    11 November 2017

A new article published in the Journal of Chemotherapy reported that Klebsiella pneumoniae K. pneumoniae has consistently remained an important cause of community acquired and nosocomial infection. This bacterium can cause catheter related infections by forming biofilm on its surface. The article elaborated on a study aimed at determining the in vitro stability and efficacy of colistin ciprofloxacin tobramycin doripenem and tigecycline alone or in combination with clarithromycin or esomeprazole as 24 hour lock solutions against biofilm embedded K. pneumoniae strains. In this experiment the efficacy of antibiotic lock solutions was tested in an in vitro catheter biofilm model against K. pneumoniae. It was observed that the use of doripenem and tobramycin as a lock solution had potent bactericidal effects. When colistin was used in combination with clarithromycin or esomeprazole the combinations had a synergistic effect. Furthermore no antagonistic effect was observed. Hence it was stated that these findings have important information for effectiveness of tested antibiotic lock solution in the catheter related infections with K. pneumoniae.1 Reference 1. Mataraci Kara E OzbekCelik B. Investigation of the effects of various antibiotics against Klebsiella pneumoniae biofilms on in vitro catheter model. Journal of Chemotherapy. 2017 1 7. doi 10.1080 1120009x.2017.1390633.

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