Ignore TSH up to 10 |

                            
                                    Choose Speciality
                                
Register

                        No new Notifications.                    
 
                        Profile

                        Change Password

                        Logout

Log In

                  Profession
                  
Mobile 
                        
                  Speciality
                                    
                 Medical Council
                  
               Registration Number

Editorial

Ignore TSH up to 10

Dr KK Aggarwal, 20 May 2019
4380 Views
#Multispeciality

An international panel of experts has concluded that patients with subclinical hypothyroidism should not be routinely offered thyroid hormone replacement therapy.In the recommendations published online this week in the BMJ, the expert panel writes “for adults with subclinical hypothyroidism, thyroid hormones consistently demonstrate no clinically relevant benefits for quality of life or thyroid-related symptoms, including depressive symptoms, fatigue, and bo

Read the full story.

Create a free account.

Create Account

Already registered?

Editorial

Ignore TSH up to 10

Dr KK Aggarwal, 20 May 2019
#Multispeciality

An international panel of experts has concluded that patients with subclinical hypothyroidism should not be routinely offered thyroid hormone replacement therapy.

In the recommendations published online this week in the BMJ, the expert panel writes “for adults with subclinical hypothyroidism, thyroid hormones consistently demonstrate no clinically relevant benefits for quality of life or thyroid-related symptoms, including depressive symptoms, fatigue, and body mass index (BMI).”

The guidance, based on findings from a systematic review and meta-analysis of 21 trials with 2192 participants published in November (JAMA. 2018;320:1349-1359) represents a “strong recommendation” against prescribing thyroid hormones (primarily levothyroxine LT4) in adults with subclinical hypothyroidism.

Subclinical hypothyroidism is defined as elevated thyroid stimulating hormone (TSH) levels when free T4 (thyroxine) levels are normal.

Subclinical hypothyroidism is known to affect around 5% of the adult population and 10-15% of the elderly.
About 90% of patients with subclinical hypothyroidism have TSH levels of 4-10 mlU/L, but a slight increase may be normal in older people.
Symptoms when present include fatigue, muscle cramps, sensitivity to cold, sluggish thinking and depression; as per the expert panel, 20-25% of people with normal thyroid levels report one or two of these symptoms.
In the majority of cases, the issue resolves itself. About 62% of people with TSH levels of 4-10 mlU/L have normalization of thyroid levels within 5 years without any treatment, states the report. The risk of overt hypothyroidism emerging from the subclinical forms of the condition ranges between 2% and 5% per year.
Observational data suggest an association between subclinical hypothyroidism and an increased risk of coronary heart disease, the associations have not been seen with TSH levels of 5-10 mIU/L.

(Source: Medscape)

Dr KK Aggarwal

Padma Shri Awardee

President Elect Confederation of Medical Associations in Asia and Oceania (CMAAO)

Group Editor-in-Chief IJCP Publications

President Heart Care Foundation of India

Past National President IMA

Instance ID Token

Needs Permission

Read the full story.

Create a free account.

Comments

Recommendations

Trending Articles

Instance ID Token

Needs Permission

Update Your Profile

LOGIN

SIGN UP

SEARCH

Email This

Read the full story.

Create a free account.

Comments

Recommendations

Trending Articles