A new study published in Experimental and Clinical Endocrinology Diabetes investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective cross sectional study recruited 1 135 subjects 64 females aged between 18 and 81 years presenting 8804 2 components of metabolic syndrome. These individuals were divided into the following groups centrally lean waist to height ratio WHtR 0.5 and waist circumference 80 8201 cm in females and 94 8201 cm in males or presenting central obesity WHtR 8805 0.5 regardless of waist circumference . The findings revealed that 5.7 males and 6.9 females presented WHtR 8805 0.5. When compared to centrally lean subjects those with central obesity had higher BMI adjusted fasting plasma glucose and leptin levels. Additionally females presented with higher blood pressure while males had higher high sensitive C reactive protein hsCRP concentrations. It was stated that these changes could be correlated to significantly higher BMI adjusted odds to present fasting plasma glucose 5.6 8201 mmol l in both genders higher odds to present hsCRP 3 8201 mg l in males and those to present elevated blood pressure in females. The findings of this study indicated that in metabolically healthy normal weight subjects WHtR 8805 0.5 might indicate an early increased health risk.