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Endotoxin and particulate matter emitted by livestock farms and respiratory health effects.

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eMediNexus    09 August 2019

A new study published in Environment International assessed exposure-response relations for a range of respiratory endpoints and atopic sensitization in relation to livestock farm associated particulate matter (PM)10and endotoxin levels.This was a population-based cross-sectional study that recorded self-reported respiratory symptoms of 12,117 participants. For 2,494 individuals, data on lung function (spirometry) and serologically assessed atopic sensitization were available. Annual-average PM10 and endotoxin concentrations at home addresses were predicted; exposure-response relations were analyzed.The findings showed that health outcomes were generally more strongly associated with exposure to livestock-farm-emitted endotoxins compared to PM10. In fact, an inverse association was noted for dispersion modelled exposure for atopic sensitizationand asthma. Prevalence of respiratory symptoms decreased with increasing endotoxin concentration at the lower range, whereas at the higher range the prevalence increased with increasing concentration. On the other hand, associations between lung function parameters with exposure to PM10 and endotoxin were not statistically significant.Hence, it was concluded that exposure to livestock farm emitted particulate matter is associated with respiratory health effects and atopic sensitization in non-farming residents. The results of tis study hint towards endotoxin as a potentially plausible etiologic agent, suggesting that non-infectious aspects of microbial emissions from livestock farms are important with respect to public health.

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